摘要
[目的]研究α干扰素(IFN-α)对慢性乙型肝炎患者血清肝纤维化指标的影响。[方法]32例慢性乙型肝炎患者,以肌肉注射IFN-α1b3MU,隔日1次,用酶联免疫吸附法(ELISA法)检测血清中透明质酸(HA)、层粘蛋白(LN)、Ⅳ型胶原(C-Ⅳ)及转化生长因子-β1(TGF-β1)含量,观察治疗前后上述血清指标的变化情况。[结果]经IFN-α治疗6个月后,血清HA、LN、C-Ⅳ、TGF-β1含量均较治疗前明显下降,差异有统计学意义(P﹤0.01);将32例慢性乙型肝炎患者分为3组:完全应答组19例、部分应答组8例,无应答组5例。只有完全应答组患者在治疗后血清LN、HA、C-Ⅳ、TGF-β1含量达到正常水平,并且上述指标的下降程度在完全应答组最明显(F≥103.6,P﹤0.01),部分应答组和无应答组织间比较差异无统计学意义。[结论]α干扰素(IFN-α)可以改善慢性乙型肝炎患者的肝纤维化。
[Objective] To investigate the influence of interferon-α （IFN-α） on the senum hepatic fibrosis index in patients with chronic hepatitis B. [Methods] 32 patients with ehronieity hepatitis B were eonduected to be. intramuscular injection by using 3MU of IFN-α per two days. The levels of byaluronie acid （HA）, Iaminin （LN）, transforming growth factor-β1 （TGF-β1） and type Ⅳ collagen （Ⅳ-C） in serum of these patients were detected by using enzyme linked immunosorbent assay （ELISA） method, and the changes of these indexes were observed before, and after treatment. [ Results] The level of HA, LN, Ⅳ-C and TGF-β1 in serum was found significantly decreased after treating by IFN-α for 6 months （P 〈 0.01 ）. 32 patients with hepatitis B were divided into three groups： completely response group with19 eases, partly response group with 8 eases and non-response group with 5 eases. Only the levels of serum HA, LN, Ⅳ-C and TGF-β1 in completely response group met to normal level, moreover, the falhing degrees of all the indexes in complete resplmse group was significant higher than those in other group （F≥103.6, P〈 0.01 ）, no significant differense was found between partly response group and iron-response group. [Conclusion] IFN-α could control tile hepatic fibrosis of patients with chronic hepatitis B.
出处
《现代预防医学》
CAS
北大核心
2008年第2期370-371,共2页
Modern Preventive Medicine
关键词
肝炎病毒
乙型
肝纤维化
干扰素
Hepatitis virus
Hepatitis B
Hepatic fibrosis
Interferon
