摘要
目的介绍脉络丛乳头状癌的病理和免疫组化特征。方法对一例脉络丛乳头状癌患者的临床表现、组织形态学和免疫组化染色进行分析,并结合文献对本病的诊断、鉴别要点进行了探讨。结果脉络丛乳头状癌的组织学形态特点:由柱状上皮围绕毛细血管、纤维组织所形成的乳头样结构。瘤细胞有异型,可见核分裂相。免疫组化示细胞角蛋白(CK)阳性,胶质纤维酸性蛋白(GFAP)、S-100及波形蛋白(Vimentin)灶性阳性,上皮膜抗原(EMA)、突触素(Syn)、神经元特异性烯醇化酶(NSE)、神经微丝(NF)及均为阴性。Ki67:>20%。PAS染色阴性。结论脉络丛乳头状癌的诊断主要依靠其组织学形态和免疫组化标记;常需与室管膜瘤、转移癌及乳头瘤型脑膜瘤鉴别。
Objective To investigate the opathological and immunohistochemical features, histogenesis and biologic behaviors of choroid plexus carcinoma. Methods One ease of choroid plexus carcinoma was studied by clinic,histopathologic criteria and immunohistochemical staining. Literatures were reviewed emphasizing the diagnostic criteria and differential diagnosis. Results The histopathologie features of choroid plexus carcinoma were composed of delicate fibrovascular connective tissue frounds covered by a single layer of uniform cuboidal to columnar epithelial cells with round or oval nuclei. The tumour shows frank signs of malignancy. Mitoses were frequent. Immunohistochemic alanalysis showed that the choroid plexus carcinoma expressed CK, GFAP, S-100 and Vimentin were expressed in some cells. The EMA, Syn, NSE and NF were all not expressed. Ki67 labelling was more than 20%. PAS stain was not found. Conclusions The diagnosis of choroid plexus tumors were made by histopathologie alanalysis and immunohistochemical staining . The ependymoma, metastatic carcinoma and papillary meningioma are relevant in the differential diagnosis of choroids plexus carcinoma.
出处
《临床神经外科杂志》
CAS
2007年第4期170-172,共3页
Journal of Clinical Neurosurgery
关键词
脉络丛肿瘤
乳头状癌
免疫组化
choroid plexus tumor
papillocarcinoma
immunohistochemistry
