摘要
目的探讨新的近红外光谱技术来测量C6胶质瘤荷瘤鼠脑局部血氧饱和度(SO2)的特点。方法利用光学探头微创测量30只C6荷瘤鼠瘤体局部SO2,并与对侧脑组织SO2进行比较。结果瘤体内SO2较正常脑组织SO2低,两者差异有统计学意义(P<0.05);有坏死或出血个体SO2曲线出现明显低峰。结论通过微创光学探头可以测量胶质瘤内SO2。
Objective To measure local cerebral blood oxygen saturation in C6 glioma rats in vivo by new near infrared spectroscopy （NIRS）. Methods 30 C6 glioma-bearing rats were measured mini-invasively by a optic fiber probe revealing SO2. Intratumoural SO2 （ tSO2 ） was compared to normal cerebral tissue SO2. Results The mean SO2 of intratumoural tissue was（55. 1 ± 4.7）%,and the mean SO2 of normal tissue was （60.7 ± 2.5）% in contralateral cerebral tissue, respeetively. The difference is significant, Conclusions Measurement of glioma in vivo by NIRS is feasible.
出处
《临床神经外科杂志》
CAS
2007年第4期145-147,共3页
Journal of Clinical Neurosurgery
基金
国家自然科学基金资助(30671997)
