摘要
本文报道金环蛇、扁颈蛇、眼镜蛇、银环蛇蛇毒及其细胞毒对小鼠S180,EAC腹水癌的治疗作用。结果表明,蛇毒及其细胞毒在体外有明显杀灭癌细胞作用,体内有较明显的治疗作用,动物存活时间延长,接种率降低。肿瘤细胞呈现不同程度形态变化,主要为膜破裂,坏死等。治疗效应由强到弱为金环蛇毒,扁颈蛇毒,金环蛇细胞毒,眼镜蛇毒,眼镜蛇细胞毒。银环蛇毒无作用。
We have observed outstanding inhibition of sarcoma 180 to ehrlich asciters in vitro and vivo of the nice.
After inoculation Bungarus fasciatus, Najanaja venoms which is purified from B.fasciatus, Naja naja and Ophiophagus into mice with S 180,EAC, survival rate increased than normal (P<0.001) and it delay the survival time and decrease the inoculating mice to transplant to other mices.
But the effects of P.O. or injection of B. multicinctus are not evident.
A series of cytomophological investigation have shown that the venoms not only act at the level of cell membrane, but also at the level of nuclear membrane leading to the change in various parts of the cells and the cytotoxin effects in vivo and in vitro are discussed in paper as well.
