摘要
目的:观察术中心肌酶的变化,评价含钾温血持续心肌灌注对心肌的保护效果。方法:18例心脏病患者根据主动脉阻断时间长短分为两组,A组(8例)<40分,B组(10例)>40分。术中应用15％氯化钾与氧合温血混合后持续灌注心肌,灌注速度15～150ml/h,温血灌注液中钾维持浓度平均7.83±0.3mmol/L。结果:两组再灌注期间肌酸磷酸激酶(CK)及其同功酶(CK-MB)、乳酸脱氢酶(LDH)差异无显著性(P>0.05),乳酸脱氢酶同功酶LDH_1与LDH_2之比均小于1;同组内再灌注期与灌注期CKMB值相比差异无显著性(P>0.05)。结论:含钾温血持续灌注对心肌的保护效果持续、可靠。
Objective:To observe the changes of the value of myocardial enzymes and evaluate the protective effects of continuous potassic warm blood perfusion on myocardium. Method:Eighteen ASA physical status Ⅱ-Ⅲ patients were divided into two groups (A and B)according to aortic crossclamp time,group A (n=8)<40 mintues, group B(n=10)>40 mintues.15％ potassium chloride was mixed with oxygenated warm blood for continuous myocardial perfusion at a rate of 15 to 150 ml/h.The average potassic concentration of normothermic blood perfusate was 7.83±0.3 mmol/L. Result:The serum concentrations of creatine kinase(CK)、creatine kinase isoenzymes(CK-MB)and lactate dehydrogenase(LDH)changed unsignificantly between group A and group B during reperfusion period (P>0.05).The serum concentrations of CK-MB changed unsignificantly between reperfusion and perfusion period in either group.In both groups LDH_1 level was less than that of LDH_2 during reperfusion period. Conclusion:Continuous potassic warm blood perfusion is reliable for myocardial protection.
出处
《中华麻醉学杂志》
CAS
CSCD
北大核心
1997年第8期453-455,共3页
Chinese Journal of Anesthesiology
关键词
温血灌注
心肌保护
心肌
酶
Warm blood perfusion
Myocardial protection
Enzymes
Myocardium
