摘要
目的:观察乌司他丁对腹腔镜下盆腔手术患者术后肝功能和应激反应的影响. 方法:40例腹腔镜盆腔手术患者,随机分成A组(乌司他丁组)和B组(对照组)各20例.A组在术前1天、术中和术后第1～3天给予20万U乌司他丁静脉滴注;B组给予生理盐水静脉滴注.两组患者分别于术前、术后第1、3、7天检测谷丙转氨酶(ALT)、谷草转氨酶(AST)、总胆红素(TBIL)、白蛋白(ALB);同时于术前、术毕及术后第1、3天测定皮质醇(Cor)和C反应蛋白(CRP) 浓度.比较两组患者术后肝功能和应激水平的变化情况. 结果:两组患者的ALT和AST术后第1、3天较术前明显升高(P ＜0.05),A组升高程度明显低于B组(P＜0.01);术后第7天两组患者ALT和AST均恢复至术前水平 (P＞0.05).两组患者术后TBIL、 ALB无明显变化(P＞0.05). 术毕及术后第1天B组患者Cor和CRP较术前明显升高(P ＜0.01),术后第3天恢复至术前水平;A组患者术后Cor和CRP无明显变化.结论:腹腔镜下盆腔手术患者应用乌司他丁对其术后肝功能具有保护作用,同时可以缓解应激反应,有重要的临床价值.
Objective： To observe the effect of ulinastatin on liver function and stress response in patients undergoing laparoscopic pelvic surgery. Methods： Forty patients undergoing laparoscopic pelvic surgery were randomly divided into 2 even groups： Group A received ulinastatin （2× 10^5 IU） on 1st preoperative day, during surgery and 1st, 2nd and 3rd postoperative day, and Group 15 only accepted normal saline. Total bilirubin, albumin, aspartate transferase （AST）, alanine transferase （ALT）, C-reative protein （CRP）, and cortisol levels in all cases were determined pre- and post-operatively. Results： There were no obviously perloperative changes in total bilirubin and albumin contents in all patients. AST and ALT levels increased on 1st and 3rd postoperative day, especially in Group B, and then returned preoperative levels on 7th postoperative day. CRP and cortisol concentrations increased on 1st postoperative day only in group B, and then returned preoperative status on 3rd postoperative day. Conclusion： Ulinastatin could provide liver protection and alleviate stress response in patients undergoing laparoscopic pelvic surgery.
出处
《广东医学院学报》
2005年第4期375-376,381,共3页
Journal of Guangdong Medical College
关键词
腹腔镜
乌司他丁
肝功能
应激
laparoseope
ulinastatin
liver function
stress
