摘要
通过动物实验．观察AC960对微管蛋白聚合—解聚活性的影响。结果显示：AC960能明显抑制微管蛋白聚合，其作用略弱于秋水仙碱，且同时有抑制微管蛋白解聚作用。说明AC960抗癌机理可能在于影响微管蛋白的聚会—解聚活性，破坏纺缍丝形成，从而抑制癌细胞有丝分裂，促进其凋亡。
The effect of AC960 was observd on polymeric-depolymeric activity of microtubulin in an ani-mal experiment. The result showed that AC960 could markedly inhibit the polymeric-depolymeric activity,which indicated that its anti-cancer effect was related to this inhibition and the prevention of the formation ofspindle fibers, thus inhibiting the mitosis of cancer cells.
出处
《南京中医药大学学报》
CAS
CSCD
1997年第5期275-276,共2页
Journal of Nanjing University of Traditional Chinese Medicine
基金
上海市教委资助
关键词
微管蛋白
聚合
解聚
AC960
microtubulin, polymerization, depolymerization, AC960
