摘要
目的:以硒蛋氨酸为参照,研究甲基硒半胱氨酸的生物利用率和毒性。方法:通过硒积累、谷胱甘肽过氧化物酶和硫氧还蛋白还原酶活力比较生物利用率,通过急性毒性和短期硒耐受实验比较毒性。结果:两者对含硒酶的影响相同。硒蛋氨酸产生更高的硒积累,尤其是在高剂量硒水平。急性致死作用和短期硒耐受试验均显示硒蛋氨酸毒性低。结论:与硒蛋氨酸相比,甲基硒半胱氨酸有相等的含硒酶调节能力,特点是硒积累少,但具有较高的毒性。
Objective： With selenomethionine as reference, we investigated the bioavailability and toxicity of methylselenocysteine. Method： Selenium retention, glutathione peroxidase and thioredoxin reductase activities were tested to compare bioavailability. Acute toxicity and short-term selenium-tolerance were studied to compare toxicity. Results： Selenomethionine and methylselenocysteine were comparable in ability of increasing selenoenzymes. Selenomethionine caused much higher selenium retention, especially at higher levels and lower toxicity indicated by acute toxicity and short-term selenium-tolerance. Conclusion： Compared with selenomethionine, methylselenocysteine has equal efficacy on selenoenzymes with the characterization of less retention, but higher toxicity.
出处
《营养学报》
CAS
CSCD
北大核心
2007年第6期544-546,共3页
Acta Nutrimenta Sinica
关键词
硒蛋氨酸
甲基硒半胱氨酸
生物利用
毒性
selenomethionine
methylselenocysteine
bioavailability
toxicity
