摘要
目的：研究不同兴奋性氨基酸受体拮抗剂（ＭＫ８０１，Ｓｐｅｒｍｉｎｅ，ＤＮＱＸ）对大鼠脑缺血时纹体缩胆囊肽－８（ＣＣＫ－８）释放的影响。方法：用微透析和ＲＩＡ法测定半球缺血时纹体ＣＣＫ－８的释放。结果：脑缺血时纹体ＣＣＫ－８释放明显增高，缺血前分别给予三种拮抗剂，都明显地降低缺血时纹体ＣＣＫ－８的不正常释放。结论：表明脑缺血时的ＣＣＫ－８和兴奋性氨基酸（ＥＡＡ）之间有协同的相互作用，抑制ＣＣＫ－８释放增高，可能是兴奋性氨基酸受体拮抗剂保护缺血大脑的机制之一。
Objective: To study the effects of different EAA receptor antagonists(NK801),Spermine and DNQX) on CCK 8 releases from ischemic rat striatum. Methods: The CCK 8 release from striatum were determined by microdialysis and RIA methods. Results: The releases of CCK 8 from rat striatum were significantly increased during cerebral ischemia and these abnormal releases of CCK 8 were remarkably inhibited by all three EAA antagonists which were administered before cerebral ischemia. Conclusion: There is a coordinated interaction between CCK 8 and EAA during cerebral ischemia and the inhibition of CCK 8 release may be one of the protective mechanism of EAA receptor antagonists to ischemi brain.
出处
《中华神经外科杂志》
CSCD
北大核心
1997年第4期222-225,共4页
Chinese Journal of Neurosurgery
基金
国家"八五"攻关
关键词
脑缺血
纹体
缩胆囊肽-8
Cerebral ischemia Striatum CCK 8 MK801 Spermine DNQX
