摘要
目的：观察蛇床子素（Ｏｓｔ）和蛇床子总香豆素（Ｔｃｒ）对肾阳虚模型大鼠和正常鼠学习记忆成绩和神经肽水平的影响。方法：用醋酸氢化可的松复制肾阳虚大鼠模型，以Ｏｓｔ和Ｔｃｒ给模型鼠和正常鼠用药。用跳台试验法测定大鼠学习记忆成绩，并用放射免疫法测定大鼠下丘脑和血浆中精氨酸升压素（Ａｒｇｉｐｒｅｓｉｎ，ＡＰ）和生长抑素（Ｓｏｍａｔｏｓｔａｔｉｎ，ＳＳ）的含量。结果：肾阳虚组与正常组比较，学习记忆成绩明显下降（Ｐ＜０．０１），ＡＰ降低而ＳＳ升高（Ｐ＜０．０１）；肾阳虚动物用药后学习记忆成绩提高（Ｐ＜０．０１），ＡＰ升高而ＳＳ下降（Ｐ＜０．０１）。但正常动物用药后，上述指标无显著性差异（Ｐ＞０．０５）。结论：Ｏｓｔ和Ｔｃｒ对模型鼠有补肾壮阳作用。
Objective: To observe the effects of osthol (Ost) and total coumarins(Tcr) of Cnidium monnieri on the grade of learning and memory (GLM) and neuropeptides in the Kidney Yang dificiency rats and the normal rats. Methods:Rats were injected intraperitoneally with hydrocortisone acetate to replicate the model of Kindey Yang deficiency. Ost and Tcr were administered orally to the model and normal rats. The GLM of rats were tested by the method of step test , and the contents of argipressin(AP) and somatostatin ( SS) in hypothalamus and plasma were determined by the method of RIA.Results: Compared with those in normal rats, GLM and the level of AP lowered significantly (P<0.01), while the content of SS increased obviously (P<0.01) in model rats. Ost and Tcr could notably raise the GLM and the level of AP, and lower the content of SS in model rats, but had no significant effects on normal rats. Conclusion: Ost and Tcr have the effects of reinforcing Kidney Yang on model rats but showed no effects on normal rats.
出处
《第二军医大学学报》
CAS
CSCD
北大核心
1997年第2期147-149,共3页
Academic Journal of Second Military Medical University
基金
国家自然科学基金
关键词
蛇床子素
香豆素
肾阳虚
学习记忆
神经肽
Osthol
coumarin
Kidney Yang deficiency
learning and memory
argipressin
somatostatin
