摘要
采用醋酸氢化可的松造成肾阳虚模型大鼠，以蛇床子素（ｏｓｔｈｏｌ，ＯＳＴ）和蛇床子总香豆素（ｔｏｔａｌ－ｃｏｕｍａｒｉｎｓ，ＴＣＲ）给药，测定大鼠血清促甲状腺激素（ＴＳＨ）和三种甲状腺激素Ｔ３、反Ｔ３（ｒＴ３）及Ｔ４的浓度。结果，肾阳虚模型大鼠与正常大鼠比较，ＴＳＨ、Ｔ３、ｒＴ３和Ｔ４都显著降低（Ｐ均＜０．０１）；用药大鼠与肾阳虚模型大鼠比较，上述４项指标都有显著性提高（Ｐ＜０．０１或Ｐ＜０．０５）。提示ＯＳＴ和ＴＣＲ可以提高肾阳虚模型大鼠的腺垂体－甲状腺轴功能。
Osthol and total coumarins of Fructus Cnidii were given to the model of Kidney-Yang Deficiency rats induced by hydrocortison acetate injection, the changes of serum concentration of thyroxine T3,reverse T3 (rT3). T4 and thyroid stimulating hormone (TSH) were observed. Results showed that in comparison with normal rats, all of the criteria mentioned above were lowered significantly (P<0. 01) in model rats. After treatment, the criteria observed were all increased significantly (P<0.01 or P<0.05). It was suggested that the osthol and total coumarins of Fructus Cnidii could elevate the pituitary-thyroid axis function of. Kidney-Yang Deficiency rats.
出处
《中国中西医结合杂志》
CSCD
北大核心
1996年第9期552-553,共2页
Chinese Journal of Integrated Traditional and Western Medicine
关键词
蛇床子素
蛇床子总香豆素
肾阳虚
大鼠
甲状腺素
Fructus Cnidii
osthol
total coumarin
modelof Kidney-Yang Deficiency
thyroxin
thyroid stimulating hormone
