摘要
目的：探讨多梗塞痴呆和Ａｌｚｈｅｉｍｅｒ型痴呆患者神经心理功能与局部脑血流的关系。方法：对３３例多梗塞痴呆（ＭＩＤ）、２１例Ａｌｚｈｅｉｍｅｒ型痴呆（ＤＡＴ）病人和２４例健康对照组作了单光子发射计算机断层显像（ＳＰＥＣＴ）检查，采用相对定量法测定局部脑血流（ｒＣＢＦ）。并作神经心理学测验。结果：ＭＩＤ病人左额颞叶ｒＣＢＦ与言语智商（ＶＩＱ）相关显著；左额、右顶、丘脑ｒＣＢＦ与总智商（ＦＩＱ）明显相关；左颞、右顶叶ｒＣＢＦ与脑损伤指数（ＤＱ）相关明显。ＤＡＴ病人左颞、右额叶ｒＣＢＦ与ＶＩＱ，右顶枕叶ｒＣＢＦ与操作智商（ＰＩＱ），左额颞、右顶叶ｒＣＢＦ与ＤＱ相关明显。ＭＩＤ、ＤＡＴ病人左颞叶ｒＣＢＦ与记忆商数（ＭＱ）相关显著。结论：提示ＭＩＤ、ＤＡＴ病人智能减退与脑血流降低有关。
Objective: To explore the relationship between regional cerebral blood flow (rCBF)and neuropsychological functions in dementia of multi-infarct and Alzheimer Type. Method:Relative quantitative analysis for regional cerebral blood flow (rCBF) with single photon emission computed tomography ( SPECT) was used in 33 patients with multi-infarct dementia(MID), 21 patients with dementia of Alzheimer Type ( DAT) and 24 age-matched controls. All subjects underwent a neuropsychological assessment.Results: ①Significant correlations were found between VIQ and rCBF in left frontal temporal cortex; FIQ and rCBF in left frontal, right parietal cortex and right thalamus; damage quotient(DQ) and rCBF in left temporal and right parietal cortex in patients with MID. ②Significant correlations were also observed between VIQ and rCBF in left temporal and right frontal cortex; PIQ and rCBF in right parietal-occipital cortex; FIQ and rCBF in left frontal-temporal and right parietal cortex; DQ and rCBF in left frontal and right parietal cortex in patients with DAT. ③Left temporal rCBF had a significant positive correlation with MQ in both MID and DAT groups. Condusion: Neuropsychological function declines with decreased rCBF to cerebral cortex in patients with MID and DAT.
出处
《中国临床心理学杂志》
CSCD
1997年第3期155-157,154,共4页
Chinese Journal of Clinical Psychology
关键词
早老性痴呆
多梗塞痴呆
脑血液
认知功能
Multi-infarct dementia
Dementia of Alzheimer type
Neuropsychological function
Cerebral blood flow
