阿立哌唑与奋乃静治疗老年精神分裂症对照研究被引量：1

导出

摘要目的:比较阿立哌唑与奋乃静治疗老年精神分裂症的疗效及不良反应。方法:80例符合CCMD-3的老年精神分裂症患者随机分为两组各40例,分别给予阿立哌唑或奋乃静治疗6周,采用PANSS量表和不良反应症状量表评定疗效和不良反应。结果:治疗6周后,阿立哌唑组的总有效率为85%,显效率为60.5%,奋乃静组的总有效率为82.5%,显效率为57.5%,两组疗效比较无统计学差异(P>0.05)。阿立哌唑的不良反应发生率为37.5%,奋乃静组为60%,两组间比较有统计学差异(P<0.05)。结论:阿立哌唑和奋乃静治疗精神分裂症疗效相当,不良反应相对较小。

作者李聪慧阎凤芝

机构地区河南第二荣康医院

出处《中国民康医学》 2007年第23期1062-1063,共2页 Medical Journal of Chinese People’s Health

关键词阿立哌唑奋乃静精神分裂症疗效不良反应

分类号 R971.4 [医药卫生—药品] R749.3 [医药卫生—神经病学与精神病学]

引文网络
相关文献

参考文献4

1朱紫青,张明园.第3代抗精神病药阿立哌唑研究进展[J].中国医院用药评价与分析,2005,5(2):121-123. 被引量：116
2王任昌,刘永红,宁志军.阿立哌唑与氯氮平治疗首发精神分裂症对照研究[J].临床心身疾病杂志,2005,11(4):301-302. 被引量：19
3Butini, Canpiani G, Angelis MD, et al. Novel antipsyehotie agents:recent advance in the drug treatment of schizophrenia[J]. Expert opinion on Therapeutic patents, 2003,13 (4):425.
4Marder SR,McQuade RD, stock E, et al. Aipipraxole in tile treat-ment of schizophrenia: Safety and tolerability in short-term place-bo-controlled trials [J]. Schizophr Res,2003,61(2-3):123.

二级参考文献19

1张璞,李中东,焦正.第二代非典型抗精神病药——阿立哌唑[J].中国药学杂志,2005,40(3):238-240. 被引量：59
2朱紫青,张明园.第3代抗精神病药阿立哌唑研究进展[J].中国医院用药评价与分析,2005,5(2):121-123. 被引量：116
3中华医学会精神科分会.中国精神障碍分类与诊断标准[M](第3版)[M].济南:山东科学技术出版社,2001.75.
4Potrin SG,Saha AR,Kujawa MJ, et al. Ariprazole: an antipsychotic with a novel mechanism of action, and risperidone vs placebo in patients with schizophrenia or schizoaffective disorder[J]. Arch Cen psychiatry, 2003,60: 681
5Aihara K, Shimada J, Miwa T, et al. The novel antipsychotic aripirazole is a partial agonist at short and long isoforms of D2receptors linked to the regulation of adenylyl cyclase activity and prolactin release[J] . Brain Research ,2004,1 003:9.
6Bourin M, Auby P, Swanink R, et al. Aripiprazole versus haloperidol for maintained treatment effect in acute mania [M]. In: New Research Abstracts of the 156th Annual Meeting of the American Psychiatric Association; San Francisco, Calif. 2003 May 20,Abstract NR467:175.
7Lieberman J, Carson WH, Saha AR, et al. Meta - analysis of the efficacy of aripirazole in schizophrenia [ J ]. Int J Neuropsychupharmacol, 2002,5 ( suppl 1 ): S186.
8Marder SR, McQuade RD, Stock E, et al .Aripirazole in the treatment of schizophrenia: safety and tolerability in short term placebo - controlled trials [ J ]. Schizophr Res, 2003,61: 123.
9Lieberman J. Aripirazole, The American Psychiatric Publishing Textbook of Psychopharmacology [ M ]. Third Edition. American Psychiatric Publishing, Inc .2004:487 ～ 493.
10McQuade RD, Jody D, Kujawa MJ, et al. Long - term weight effects of aripiprazole versus olanzapine [ M ] . In: New Research Abstracts of the 156th Annual Meeting of the American Psychiatric Association. San Francisco, Calif. 2003May 19, Abstract NR231:86.