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nm23-H_1在慢性粒细胞白血病患者血浆中的表达及临床意义 被引量：1

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摘要 采用酶联免疫法测定分化抑制因子nm23-H1蛋白在80例慢性粒细胞白血病(CML)患者(观察组)和30例健康志愿者(对照组)血浆中的含量。结果观察组慢性期(CML-CP)nm23-H1蛋白血浆水平与对照组无显著差异,加速期(CML-AP)、急变期(CML-BP)明显高于对照组(P<0.001),CML-BP明显高于CML-AP。认为nm23-H1蛋白在CML血浆中的表达水平与疾病进展有关,nm23-H1蛋白表达水平可为CML早期诊断、临床分期及预后判断提供新的评价手段及实验室依据。
作者 张瑞英 魏红 乔泽涛 栗军香 潘崚 杨俊超
机构地区 河北工程大学附属医院 邯郸铁路医院 河北医科大学第二医院
出处 《山东医药》 CAS 北大核心 2007年第35期51-52,共2页 Shandong Medical Journal
基金 邯郸市科技局2006指导性课题资助项目(200610808-15)
关键词 白血病 慢性粒细胞 分化抑制因子 NM23-H1蛋白 酶联免疫反应
分类号 R733.72 [医药卫生—肿瘤]
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参考文献6

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二级参考文献12

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山东医药
2007年 第35期

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