摘要
家兔静往蚯蚓纤溶成分F2，观察其整体抗凝、促纤溶及溶血栓作用。与给药前比较，给药后20分钟凝血时间明显延长（P＜0．05），给药后20min及1h凝血酶原时间明显延长（皆P＜0．05），给药后4h及5h血浆纤维蛋白原含量明显降低（皆P＜0．01），给药后1，2，3小时血浆代球蛋白溶解活性均见升高趋势，给药后24h，血栓模型的检重明显减轻（P＜0．05）。
The in vivo anticoagulative and thrombolytic effects of fibrinoytically active component ofearthworm (F2) were studied in rabbits. Twenty minutes after the intravenous injection of F2, coagulation time wassprolonged signficantly compared to that before the injection (P<0. 05). Prothrombin time was also prolonged 20minutes and 1h after the injection (P< 0. 05). In addition, plasma fibrinogen contents at 4 and 5 hours after intravenous injection of F2 were decreased (P< 0. 01), and the fibrinoytic activities of euglobin at 1,2, and 3 hours after the injection tended to increase. The weight of the thrombi obtained form pulmonary artery thrombus model wasreduced significantly 24 hours after given F2 (P< 0. 05).
出处
《心肺血管病杂志》
CAS
1997年第3期228-230,共3页
Journal of Cardiovascular and Pulmonary Diseases
关键词
蚯蚓
抗凝
纤溶
溶栓
药理
Earthworm
Anticoagulation
Fibrinoysis
Thrombolysis
