期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

硝苯地平控释片联合氟伐他汀治疗高血压左室肥厚的疗效观察 被引量：4

暂未订购
导出
摘要 目的硝苯地平控释片联合氟伐他汀治疗高血压左室肥厚,观察其疗效及不良反应。方法选择门诊或病区36例高血压左室肥厚患者,口服拜新同30～60mg/d+来适可40mg/d,观察血压、室间隔厚度、左室后壁厚度、左室舒张末期内径、左室射血分数、左室重量指数以及不良反应,疗程24周。结果24周末,左室间隔厚度、左室后壁厚度、左室重量指数均明显下降,不良反应轻微。结论硝苯地平控释片联合氟伐他汀治疗高血压左室肥厚疗效明显,不良反应轻微,值得推广。
作者 潘仁友 宋俊 伍德明 陈芹梅
机构地区 江苏省盐城市中医院心内科
出处 《中国现代医生》 2007年第11Z期27-27,29,共2页 China Modern Doctor
关键词 原发性高血压 左室肥厚 左室重量指数 硝苯地平控释片 氟伐他汀
分类号 R541.3 [医药卫生—心血管疾病]
  • 相关文献

参考文献4

二级参考文献10

  • 1Patel R,Nagueh SF,Tsybouleva N,et al.Simvastatin induces regression of cardiac hypertrophy and fibrosis and improves cardiac function in a transgenic rabbit model of human oypertrophic cardiomyopathy[J].Circulation,2001,104:317-324.
  • 2Lou JD,Zhang WW,Zhang GP,et al.Simvastatin inhibits cardiac hypertrophy and angiotensin-converting enzyme activity in rats with aortic stenosis[J].Clin Experi Pharmacol Physiol,1999,26:903-908.
  • 3Nahrendorf M,Hu K,Hiller KH,et al.Impact of hydroxymethylglutaryl coenzyme A reductase inhibition on left ventricular remodeling after myocardial infarction[J].JACC,2002,9(40):1695-1700.
  • 4Hayashidani S,Tsutsui H,Shiomi T,et al.Fluvastatin,a 3-hydroxy-3-methylglutaryl coenzyme a reductase inhibitor,attenuates left ventricular remodeling and failure after experimental myocardial infarction[J].Circulation,2002,105:868-873.
  • 5Bauersachs J,Galuppo P,Fraccarollo D,et al.Improvement of left ventricular remodeling and function by hydroxymethylglutaryl coenzyme a reductase inhibition with cerivastatin in rats with heart failure after myocardial infarction[J].Circulation,2001,104:982-985.
  • 6Laufs U,Kilter H,Konkol C,et al.Impact of HMG CoA reductase inhibition on small GTPase in the heart[J].Cardiovasc Res,2002,53:911-920.
  • 7Bergmana MW,Rechner C,Freund C,et al.Statins nhibit reoxygenation-induced cardiomyocyte apotosis role for glycogen sythase kinase 3βand transcription factor β-catenin[J].J Mol Cell Cardiol,2004,37:681-690.
  • 8Patel R,Nagueh SF,Tsybouleva N,et al.Simvastatin induces regression of cardiac hypertrophy and fibrosis and improves cardiac function in a transgenic rabbit model of human hypertrophic cardiomyopathy[J].Circulation,2001,104:317-324.
  • 9Chen MS,Xu FP,Wang GP,et al.Statins initiated after hypertrophy inhibit oxidative stress and prevent heart failure in rats with aortic stenosis[J].J Mol Cell Cardiol,2004,37:889-896.
  • 10Dechend R,Fiebeler A,Park JK,et al.Amelioration of angiotensin Ⅱ-induced cardiac injury by a 3-hydroxy-3-methylglutaryl coenzyme a reductase inhibitor[J].Circulation,2001,104:576-581.

共引文献55

同被引文献18

引证文献4

二级引证文献16

中国现代医生
2007年 第11Z期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部