摘要
目的:评价应用精氨酸(Arg)联合谷氨酰胺(Gln)的肠外营养(PN)对胃癌病人术后营养状况、免疫功能和应激状态的影响。方法:将80例胃癌病人随机分为Arg组、Gln组、Arg+Gln组及常规PN组(Rou组),每组20例。术后给予添加不同免疫营养素的PN1周,观察各组的营养状况、免疫功能和应激状态的变化。结果:术后第8天时,Arg组、Gln组和Arg+Gln组均比Rou组更能维持胃癌术后病人的营养状态,差异均有显著性意义(P<0.05);Arg组、Gln组和Arg+Gln组均比Rou组更能改善胃癌病人术后的免疫功能,差异均有显著性意义(P<0.05),其中Arg+Gln组与Rou组相比,差异有极显著性意义(P<0.01);Arg组、Gln组和Arg+Gln组与Rou组比更能抑制胃癌病人术后的应激反应,差异均有显著性意义(P<0.05),其中C反应蛋白Arg+Gln组比Rou组差异有极显著性意义(P<0.01)。结论:Arg联合Gln的PN比单用Arg或Gln的PN对增强胃癌根治术后病人细胞免疫功能、抑制其应激反应更为明显。
Objective：To evaluate the effect of Arg and Gln enriched PN on nutrition status, immune function and stress status of gastric cancer patients after radical treatment. Methods ： Eighty patients with gastric cancer were randomly divided into 4 groups ： arg group （ arginine enriched PN group） , Gin group （glntamine supplemented PN group ）, Arg ＋ Gin group （arginine and glutamine enriched PN group） and Rou group （ Routine PN group）. The distinct immune nutrients were added into PN in the different groups for 7 consecutive days. The difference of the patients＇nutrition status, immune function and stress status were analyzed after operation. Results ： The nutritional station and immunue ruction in Arg group, Gln group and Arg ＋Gln group were better than in Rou group on the 8th postoperative day. The concentration of CRP in the Arg ＋Gln group was different from that in other groups （ P 〈 0.01 ）. Conclusion： The usage of PN with arginine and glntamine is more effective in enhancing the cellular immunue ruction and suppressing the inflammatory reaction in gastric cancer patients.
出处
《肠外与肠内营养》
CAS
2007年第6期353-355,358,共4页
Parenteral & Enteral Nutrition
关键词
肠外营养
精氨酸
谷氨酰胺
胃癌
免疫
应激反应
Parenteral nutrition
Arginine
Gtutarnine
Gastric cancer
Immane function
Stress reaction
