摘要
目的:近年胃粘膜肠化与胃癌的关系引起人们的广泛重视,本文进一步探讨了二者之间的内在联系。方法:采用 ABC 免疫组织化学技术对230例肠化及胃癌组织中双花扁豆凝集素(DBA)受体的表达进行观察。根据粘液组织化学染色将胃癌分为肠型及胃型等,将肠化分为Ⅰ、Ⅱ及Ⅲ三型。结果:Ⅲ型肠化在肠型胃癌旁肠化及异型增生伴肠化的检出率均显著高于胃型胃癌旁肠化及胃炎伴肠化(P 均<0.01);肠型胃癌的 DBA 受体表达率及硫酸粘液检出率均显著高于胃型胃癌(P 均<0.01);Ⅲ型肠化 DBA 受体表达率显著高于Ⅰ、Ⅱ型肠化(P<0.05～0.01)。结论:Ⅲ型肠化与肠型胃癌关系密切,加强对Ⅲ型肠化的密切随访,对胃癌的早期发现可能具有重要意义。
Objective:We deeply studied the relation between intestinal metaplasia and gastric carci- noma,and hoped it could be of help in identifing patients of developing cacinoma.Methods:The expres- sion of dolichos biflorus agglutinin(DBA)receptors was investigated in gastric specimens of 65 gastric carcinoma(GC),53 dysplasia and 165 intestinal metaplasia(IM)with lectin-binding histochemical stain- ing method.With mucohistochemical staining,IM was classified into types Ⅰ,Ⅱ,and Ⅲ,GC was classi- fied into intestinal and gastric types.Results:The results showed that the prevalence of the type Ⅲ IM in IM specimens from intestinal type GC and from dysplasia was significantly higher than thoes from gastric type GC and from chronic gastritis(P<0.01,respectively).No difference in the prevalence of types Ⅰ and Ⅱ IM was found among the various gastric disease states(P>0.05,respectively),the expression rate of DBA receptors and the prevalence of sulphomucin in intestinal type GC were significantly higher than those in gastric type GC(P<0.01,respectively).Of variants of IM,the expression rate of DBA receptors in type Ⅲ IM was significantly higher than those in type Ⅰ and type Ⅱ IM(P<0.05～0.01). Conclusion:These results suggest that type Ⅲ IM is closely related to the development of intestinl type GC,type Ⅲ IM should be considered as precancerous lesion of gastric carcinoma of intestinal type.The presence of type Ⅲ IM in gastric biopsies may possibly be.of help in identifing patients at greater risk of developing carcinoma.
出处
《河南医学研究》
CAS
1997年第3期209-212,共4页
Henan Medical Research
关键词
胃肿瘤
癌
肠化生
凝集素
受体
gastric carcinoma
intestinal metaplasia
dysplasia
lectin
