摘要
目的实验研究褪黑素(Melatonin,MLT)对小鼠睡眠的影响并观察其治疗睡眠障碍的疗效。方法以翻正反射为指标研究褪黑素对小鼠睡眠的影响。选择30例失眠患者以褪黑素和安定对比治疗,采用显效率、有效率及SEQ评分来判断临床治疗的效果。结果中、高剂量组小鼠入睡时间均短于对照组(P<0.05),表明该检品具有促进小鼠入睡的作用;同时观察到各剂量组小鼠睡眠时间均长于对照组(P<0.05,P<0.01),表明该检品具有延长小鼠睡眠时间的作用;治疗组显效率和有效率分别为53.3%和93.3%,对照组显效率和有效率分别为50.0%和83.3%,两组疗效相似(P>0.05)。结论褪黑素具有催眠效应。
Objective： To explore the effects of melatonin on the mice＇s sleep and observe the clinical efficiency on sleep disorder. Methods To determine the sleep time by observing the loss of righting reflex method in mice, compound the MLT vs Diazeparnum treatment of 30 insomniacs, statistical analysis has been conducted between the sleep index and clinical efficiency before and after treatment. Results The sleeping times of the groups with middle and high quantity are earlier than check group （ P 〈 0.05 ）, which means the check medicine can increase the sleeping quality. The sleeping length of all dosage groups are much longer than check group, which means the check medicine prolong sleeping time of the mice. In the treantment groups, 53.3 % were markedly improved according to CGI. the rate of to total improvement was 93.3 %. In the check group, 50.0 % were markedly improved according to CGI. The rate of to total improvement was 83.3 %. Conclusion MLT has the effects of hypnogenesising.
出处
《菏泽医学专科学校学报》
2007年第3期16-17,共2页
Journal of Heze Medical College
关键词
褪黑素/生理学
巴比妥钠
安定
催眠效应
睡眠障碍
melatonin/physiology
pentobarbital sodium
diazepamum
hypnogenesising
somnipathy
