摘要
通过培养的免主动脉血管平滑肌细胞(VSMC)氚-胸腺嘧啶核苷掺入量和培养液中超氧化物歧化酶(SOD)、脂质过氧化物、前列环素(PGI2)及环磷酸腺苷(cAMP)的测定,观察了当归注射液对VSMC增殖的影响。结果表明:当归注射液有抑制VSMC增殖的作用,其作用呈剂量依赖关系。当归注射液可能通过增加SOD活性,降低脂质过氧化物水平,升高PGI2、cAMP水平(P均<0.05),从而抑制VSMC增殖。
The effects of angelica injection on the proliferation of cultured rabbit aortic smooth muscle cells(SMC)were studied with 3 H thymidine(3H TdR)incorporation data of SMC and contents of superoxide dismutase(SOD),lipid peroxide(LPO),prostacyclin(PGI 2)and cyclic AMP(cAMP)in medium.The results showed that angelica injection may inhibit SMC proliferation by increasing SOD activity,decreasing LPO,raising PGI 2 and cAMP(all P<0.05),and the inhibitory action accompanied with the dose effect relation.
作者
李自成
李庚山
黄从新
许家琍
江洪
赵志明
李晓燕
Li Zicheng;Li Gengshan;Huang Congxin(Department of Cardiology,First Afiliated Hospital Hubei Medical University,Wuhen 430060,China)
基金
湖北省科委重点资助项目
关键词
当归注射液
主动脉
平滑肌
细胞增殖
药理
plant extracts/PD
cells,cultured
muscle,smooth,vascular
thymidine
