摘要
为探讨高血压大鼠（ＳＨＲ）心肌胶原增生与心肌局部血管紧张素Ⅱ（ＡｎｇⅡ）、醛固酮（Ａｌｄ）的关系。方法应用羟脯氨酸法测定大鼠心肌胶原含量，用放免法测定心肌局部ＡｎｇⅡ、Ａｌｄ含量，将两者进行线性相关分析。结果自发性高血压大鼠（ＳＨＲｎ＝７）与对照组（ＷＫＹｎ＝７）相比，心肌胶原含量增加（Ｐ＜０．０１）。相关分析表明，心肌胶原含量与心肌局部ＡｎｇⅡ含量呈正相关（ｒ＝０．７２，Ｐ＜０．０５），与心肌局部Ａｌｄ含量呈显著正相关（ｒ＝０．８８５，Ｐ＜０．００１），而与血压（ＳＢＰ）无明显相关（ｒ＝０．３９８，Ｐ＞０．０５）。结论ＳＨＲ心肌胶原含量较正常大鼠增加，并且与心肌局部ＡｎｇⅡ、Ａｌｄ含量增加有关。
Aim\ To study the relationship between myocardial collagen concentration and local angiotensin Ⅱ(Ang Ⅱ),aldosterone(Ald) concentration in spontaneosly hypertensive rats(SHR).\ Methods\ The myocardial collagen concentration was measured by biochemical method,the local AngⅡ, Ald concentration were measured by radioimmunoassay.\ The linear correlation between them was analysed.\ Results\ Compared with WKY rats,the myocardial collagen concentration was significantly increased in SHR (7 88±1 0 vs 5 53±0 09 mg/kg tissue, P <0 01),which positively correlated with local AngⅡ( r =0 72, p <0 05) and Ald concentration ( r =0 885, P <0 01).No positive correlation was showed between myocardial collagen concentration and blood pressure( r =0 398, P >0 05).\ Conclusion\ The myocardial local AngⅡ, Ald may play roles in the accumulation of myocardial collagen in SHR.
出处
《高血压杂志》
CSCD
1997年第1期17-19,共3页
Chinese Journal of Hypertension
关键词
设备在压
大鼠
心肌胶原
血管紧张素II
醛固酮
spontaneosly hypertensive rats
myocardial collagen
angiotensin Ⅱ
aldosterone
