摘要
目的：测定高血压患者ＱＴ离散度及美托洛尔对其影响。方法：１２０例高血压患者和３０例健康人作ＱＴ离散度测定，患者中随机抽取５０例进行美托洛尔治疗，并和未治疗组７０例作为对照。结果：（１）高血压患者的ＱＴ离散度明显高于健康人（３９．４８±７． ９２ ｍｓ ｖｓ ３４．３５±１０． ６２ ｍｓ， Ｐ＜０．０５）；（２）左室肥厚者的ＱＴ离散度明显高于无左室肥厚者（５８．４３±８．９４ ｍｓ ｖｓ ３９．９１± １０． １３ ｍｓ，Ｐ＜０． ０１）；（３）高血压患者伴心率失常者明显高于无心律失常者（５５．３６±９．３３ ｍｓ ｖｓ ３８．７１±７．９６ ｍｓ，Ｐ＜０．０５）；（４）经美托洛尔治疗后其ＱＴ离散度明显缩短。结论：高血压左室肥大和心律失常者ＱＴ离散度明显增加。美托洛尔治疗使ＱＴ离散度明显缩短，有利于防止恶性心律失常。
Objective: To detect the changes of QT interval dispersion(QTd) in hypertension and the effects of metoprolol on the QTd. Methods: The QTd was measured in 120 cases of hypertension and 30 healthy people. 50 patients were recruited random from 120 cases and treated by metoprolol,the 70 cases served as controls. The QTd was measured before and two weeks after the treatments. Results: (1)The QTd in hypertension was significantly prolonged than healthy people (39. 48± 7. 92 ms vs 34. 35 ± 10. 62 ms, P<0. 05); (2) The QTd in left ventricular hypertrophy was obviously increased than non-left ventricular hypertrophy (58. 43±8. 94 ms vs 39. 91 ± 10. 13 ms,P<0.01 ) ; (3)The QTd in hypertension patients with ventricular arrhyth mias was obviously increased than without ventricular arrhythmias (55. 36± 9. 33 ms vs 38. 71 ± 7. 96 ms,P<0. 05); (4)The treatments of patients with metoprolol significantly reduced QTd (32. 61±8. 68 ms vs 50. 73± 10. 18 ms,P<0. 05). Conclusion: The QTd was prolonged in hypertension, which was related to the left ventricular hypertrophy. The QTd in hypertension with ventricular arrhythmias was obviously increased. Metoprolol could diminish the QTd in hypertension, which is beneficial for preventing malignant ventricular arrhythmia.
出处
《高血压杂志》
CSCD
2000年第1期26-27,共2页
Chinese Journal of Hypertension
关键词
高血压
QT离散度
美托洛尔
治疗
Essetial hypertension
QT interval dispersion
Metoprolol
