摘要
目的对职业接触三氯乙烯（TCE）引起皮肤和肝脏损害的临床表现进行探讨。方法对2004-2006年深圳发生的7例典型TCE中毒病人进行调查，记录每个病人的职业接触情况、主要临床症状和体征，对血常规、肝功能、尿常规、尿三氯乙酸（TCA）、心电图进行检查分析。结果7例中毒病人中6人发生在电子厂与五金制品厂；TCE接触工龄19～43d，平均30．6d；具有头晕、头痛、皮肤瘙痒、发热的比例分别为85．7％、71、4％、100．0％和57．1％；具有皮肤红斑、皮疹、水疱的病人分别为100．0％、57．1％和42．8％；肝肿大3人，尿蛋白阳性2人；ALT、AST、总胆红素（TBIL）异常率分别为100．0％、85．7％、57．1％；心电图检查异常3人，尿三氯乙酸TCA升高5人。结论三氯乙烯中毒可引起神经系统、皮肤、肝脏损害，并对心脏、肾脏也有一定影响，应深入研究其中毒机制，以保护工人身体健康。
[ Objective] To explore the clinical manifestations of dermal and liver damage induced by occupational exposure to trichloroethylene （ TCE ）. [ Methods] Investigation was carried out on 7 cases of TCE poisoning during 2004-2006 in Shenzhen ; record was made on the patients＇ information like occupational exposure period, major clinical symptoms and signs; examination was made on their routine blood, liver function, routine urine, TCA and ECG. [ Results] 6 out of 7 poisoned patients came from electronic factories and metal hardware factories; TCE exposure period was 19 to 43 days （ average 30.6 days） ; 85.7% , 71.4% , 100% and 57. 1% of the patients had symptoms of headache, dizziness, skin itch and fever respectively; 100% , 57. 1% and 42.8% of the patients had skin erythema, rashes, and blisters respectively; 3 patients had enlarged liver, 2 patients had positive urinary protein; the abnormal rates of ALT, AST, TBil were 100% , 85.7% and 57.1% respectively; 3 patients and 5 patients were found with abnormal ECG and urinary TCA increase respectively. [ Conclusion] TCE poisoning can cause multi-organ impairment, including nervous system, skin, and liver, sometimes heart and kidney are also impaired; further study should be carried out on the poisoning mechanism in order to protect the workers physical health.
出处
《职业与健康》
CAS
2007年第23期2143-2144,共2页
Occupation and Health
关键词
三氯乙烯
中毒
皮肤
肝脏
Trichloroethylene
Poisoning
Skin
Liver
