摘要
目的利用颈部挥鞭伤动物模型,观察不同加速度作用对颈部的致伤特点,为颈部挥鞭伤发生机制及救治措施的研究提供重要的实验依据。方法利用颈部挥鞭伤仿真发生装置建立不同加速度下犬颈部挥鞭伤的实验模型。结合联合行为评分(CBS)、神经病理学观察、磁共振成像(MRI)以及对致伤后的狗进行解剖过程中肉眼观察其颈部皮下组织、肌肉、软组织和肺组织有无大体损伤等一系列方法,观察颈部损伤的伤情特点以及损伤程度和牵引加速度之间的关系。结果致伤后颈段脊髓病理切片的常规光镜镜检可以发现颈段脊髓出现的病理损伤改变,行为学上表现出颈部脊髓损伤的特点,揭示在不同致伤加速度伤作用后犬颈段脊髓的神经传导功能受到不同程度的损害。结论本实验的研究结果为颈部挥鞭伤发生机制、安全防护措施及救治措施的研究提供重要的实验依据。这些伤情特征将对挥鞭伤防护方案的后续深入研究、减少交通事故中的挥鞭伤发生率以及对挥鞭伤患者的救治有重要意义。
Objective Utilizing cervical part whiplash injury animal model, to explore the traumatic condition of cervical whiplash injury of different drawing acceleration and to afford the important experimental evidence for the studies of whiplash injury occurrence mechanism,safe protect and remedy measures. Methods Based on the actual occurrence process of cervical whiplash injury, the new-style occurring equipment of cervical whiplash injury was designed, and a dog model of cervical whiplash injury at the various drawing acceleration was built. Combining with a series of measures, including combined behavioral score （CBS） and neuro patholoical general light microscope observing,magnetic resonance imaging （MRI） and examining anatomical lesion of cervical part subcutaneous tissue, muscle, soft tissue and lungs through macroscopic observation, to observe injury traits of cervical part and to investigate the relationships between degree of injury and drawing acceleration. Results The conventional light microscope exami- ning of the cervical spinal cord pathological section could discover the change of the pathological damage. It was shown the function feature of the cervical spinal cord injury in the praxiology. Which suggested the nerve conduction of cervical spinal cord had suffer lesion. Conclusion The home-made cervical part whiplash injury vulnerating equipment can do better to simulate the movement condition of occupantsr head and neck of different drawing acceleration in the motor vehicle rear-impact. After injury, the cervical spinal cord suffers different degree trauma.
出处
《重庆医学》
CAS
CSCD
2007年第17期1734-1735,1738,共3页
Chongqing medicine
基金
GM中国科学基金资助项目(30122202)
关键词
挥鞭挥
CBS
脊髓
神经行为
神经病理
神经生理
EP
whiplash injury
CBS
spinal cord injury
neuroethology
neuropathology
neurophysiology
EP
