摘要
目的观察外周血干细胞移植（PBSCT）治疗血液肿瘤临床疗效。方法自2001年3月～2007年4月，对283例血液肿瘤患者施行外周血干细胞移植，其中自体移植231例，异基因移植52例，观察其临床疗效和并发症。结果除1例ALL外，230例患者行自体外周血干细胞移植后造血功能均快速重建。异基因移植中急性移植物抗宿主病发生率23.1%，慢性移植物抗宿主病发生率21.2%，其中局限型占15.4%；9例患者于移植后1～16个月分别死于移植物抗宿主病、感染和疾病复发或进展，35例患者已无病存活3～46个月。结论外周血干细胞移植是治疗血液肿瘤的有效方法，依据患者疾病诊断、年龄、身体状况、供者情况选择移植方式。
Objective To evaluate the therapeutic effect of peripheral blood stem cell transplantation （PBSCT） for hematologic malignancies. Methods Two hundred and eighty-three patients with hematologic malignancies were included in PBSCT （allogenetic PBSCT in 52 patients, autologous PBSCT in 231 patients） from March 2001 to April 2007, then, the therapeutic effect and complication were oberserved, respectively. Results Hematopoieteic reconstitution was quickly obtained after autologous PBSCT in 230 patients except for one case with ALL. The incidence rate of acute GVHD was 23.1 %, and chronic GVHD was 21.2%, and limited GVHD was 15.4%. Nine patients died of GVHD, infection, disease relapse or development from 1 to 16 months, and thirtyfive patients were disease-free survival （DFS） from 3 to 46 months. Conclusion PBSCT is effective for the treatment of hematologic malignancies, and it is strongly suggested to select suitable mode of transplantation on account of the diagnose of disease, age and physiclal status of patient and the condition of donor.
出处
《重庆医学》
CAS
CSCD
2007年第17期1709-1712,共4页
Chongqing medicine
基金
重庆市医学重点学科建设基金资助项目(2006C028)
第三军医大学新桥医院"1520人才培养工程"基金资助项目(2006)
关键词
血液肿瘤
外周血干细胞移植
自体
异基因
hematologic malignancies
peripheral blood stem cell transplantation
autologous
allogenetic
