摘要
目的探讨2型糖尿病(T2DM)一级亲属糖耐量正常者血糖、血脂和C反应蛋白(CRP)的变化,了解T2DM自然病程中一些早期生理改变,提出预防措施。方法选择T2DM一级亲属糖耐量正常者(93名)为试验组,3代无糖尿病家族史健康者(93名)为对照组,对2组的体重指数(BMI)、糖化血红蛋白(HbAlc)、口服葡萄糖耐量试验(OGTT)葡萄糖、血脂、CRP观测指标进行比较分析.结果T2DM一级亲属糖耐量正常者与3代无糖尿病家族史的健康者BMI、OGTT试验的30、60、120min血糖及OGTT葡萄糖曲线下面积(GluAUC)、甘油三脂(TG)、CRP比较差异有显著意义.结论T2DM一级亲属糖耐量正常者已存在血糖、血脂、CRP潜在或异常的变化,在糖耐量正常阶段就应该采取糖尿病的综合预防措施,这有助于预防或延缓T2DM的发生。
Obieotive To evaluate the changes of glucose, lipid and C -reactive protein （CRP） in the first degree relatives of type 2 diabetes mellitus （T2DM） with normal glucose tolerance so as to understand the T2DM＇s early physiological changes in the natural courses and propose the preventive measures. Methods 93 T2DM＇ s first degree relatives with normal glucose tolerance were chosen as the experimental group and 93 healthy people whose family history hadn＇t diabetes in HbA1 C, OGTF, lipids and CRP were compared three degenerations as the control group. Body mass indexes between the two groups. Results There was significant statistic difference between the two groups in BMI, OGTF 30 min Glu, OGTF 60 min Glu, OGTF 120 min Glu, GluAUC, TG and CRP. Gonolusion The T2DM＇ s first degree lipids and CRP. So in the normal glucose tolerance prevent or delay the progress of T2DM. relatives had some potential or different changes in glucose stage we should take some preventive measures which would prevent or delay the progress of T2DM.
出处
《昆明医学院学报》
2007年第5期85-88,共4页
Journal of Kunming Medical College
基金
云南省教育厅科学研究基金(04Y014C)
关键词
2型糖尿病
一级亲属
正常糖耐量
血糖
血脂
C反应蛋白质
预防措施
Type 2 diabetes mellitus
First degree relatives
Normal glucose tolerance
Glucose
Lipids
C - reactive protein
Preventive measures
