摘要
近年来深部真菌感染率不断升高,而目前临床上现有的抗真菌药物均存在较大缺陷,难以满足治疗所需,因此寻找全新结构类型和全新作用机制抗真菌先导化合物对研发新一代抗真菌药物具有重要意义。本文综述了近年来新报道的抗真菌先导化合物,详细讨论了它们的化学结构、抗真菌活性和构效关系,并评述了它们的现有问题和未来发展方向。
In recent years, the incidence of infections caused by invasive fungal pathogens has increased dramatically. However, most antifungal agents used in clinic have many drawbacks and cannot meet the demand of the clinical use. Therefore, for the development of new generation of antifungal agents, it is of great significance to find antifungal lead compounds with novel chemical scaffolds and new mode of action. Novel antifungal lead compounds reported in recent years are reviewed. Their chemical structures, antifungal activity and structure-activity relationship are discussed in detail, and current problems and trends in future research are also emphasized.
出处
《药学学报》
CAS
CSCD
北大核心
2007年第11期1129-1136,共8页
Acta Pharmaceutica Sinica
基金
国家自然科学基金重点项目(30430750).
关键词
抗真菌
先导化合物
构效关系
antifungal
lead compounds
structure-activity relationship
