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固定化脂肪酶催化合成(R)-3-氯-1-苯丙醇 被引量：3

Synthesis of (R)-3-Chloro-1-phenylpropan-1-ol by Immobilized Lipase-catalytic Hydrolysis
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摘要 3-氯-1-苯丙酮经NaBH_4还原、丁酰化,然后用商业化固定化脂肪酶CRL水解拆分得98%ee的(R)-3-氯-1-苯丙醇,总收率约为41%。 （R）-3-Chloro-l-phenylpropan-l-ol was synthesized from 3-chloropropiophenone by reduction with NaBH4 and acylation to give 3-chloro-l-phenylpropyl butyrate followed by enzymatic hydrolysis with immobilized Candida rugosa lipase in overall yield of 41% with ee of 98 %.
作者 龚大春 李德莹 田毅红 韦萍 欧阳平凯
机构地区 三峡大学化学与生命科学学院 南京工业大学制药与生命科学学院
出处 《中国医药工业杂志》 CAS CSCD 北大核心 2007年第11期758-759,共2页 Chinese Journal of Pharmaceuticals
基金 湖北省教育厅重点项目(D20061300)
关键词 (R)-3-氯-1-苯丙醇 酶催化 固定化脂肪酶CRL 合成 （R） -3-chloro-1-phenylpropan-1-ol enzyme catalysis immobilized Candida rugosa lipase synthesis
分类号 Q814.9 [生物学—生物工程]
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参考文献6

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同被引文献55

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中国医药工业杂志
2007年 第11期

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