摘要
采用酶联免疫吸附法检测20例初治菌阳肺结核病人和25例健康人血清的可溶性白细胞介素-2受体(sIL-2R)水平并采用生物活性检测法同时检测外周血白细胞介素-2膜受体(mIL-2R)的表达。结果表明,肺结核病人血中sIL-2R明显增高(P<0.01),而mIL-2R则明显低于对照组(P<0.01)。提示肺结核病人体内淋巴细胞活化产生大量的sIL-2R,并在结核病中起运输白细胞介素-2(IL-2)的作用。
The levels of soluble interleukin-2 receptors (sIL-2R) were determined with ELISA in serum of 20 patients with pulmonary tuberculosis before chemotherapy. Meanwhile, the expression of membrane interleukin-2 receptor (mIL-2R) in peripheral blood mononuclear cells were also evaluated, using health persons as controls the results showed that the level of slL-2R was significantly higher (P<0.01) and the expression of mIL-2R was lower in tuberculosis group than in normal controls (P<0.01)The results showed that the activation of lymphocyte produced a great deal of sIL-2R in tuberculosis patients, sIL-2R may play an important role in transportation of interleukin-2 in tuberculosis.
出处
《中国防痨杂志》
CAS
1997年第2期89-90,共2页
Chinese Journal of Antituberculosis
