摘要
本实验采用ＥＬＩＳＡ方法，测定了狼疮性肾炎患者血清中可溶性白细胞介素－２受体（ｓＩＬ－２Ｒ）浓度的变化。结果表明：狼疮性肾炎患者血清中ｓＩＬ－２Ｒ水平明显高于正常对照组（Ｐ＜０．０１）。该结果提示狼疮性肾炎患者的细胞免疫功能低下与ｓＩＬ－２Ｒ有密切关系。ｓＩＬ－２Ｒ可能是通过阻断白细胞介素－２（ＩＬ－２）介导的细胞免疫反应而导致狼疮性肾炎的发病。本实验方法简便易行，便于临床推广使用，并可作为临床观察病情变化及判定疗效的一种新的、有用的指标。
oluble Interleukin-2 Receptor(SIL-2R) is
an immunodepressive factor. Its significance in immunediseases has
drawn considerable attention. We detected serum sIL-2R level with
ELISA method, stud-ied its role in lupus(LE) nephritis. 21 cases
(20～47 years of age) of LE nephritis and 18 cases(22～45years of
age)of normal control were enrolled in this study.sIL-2R level was
significantly higher thanthat of the normal control(P<0. 01 ).LE
nephritis is an autoimmune disease with abnormal cellularimmunity.
The results of this test indicated that attenuated cellular immunity
was strongly correlatedwith sIL-2R, The possible mechanism was that
by blocking the activity of IL-2, IL-2 mediated cellularimmunity was
depressed.which led to the occurrence of nephritis. This test can be
used as an effectiveindex for LE.
出处
《中国医科大学学报》
CAS
CSCD
1995年第1期36-37,共2页
Journal of China Medical University
关键词
狼疮性肾炎
白细胞介素2
细胞免疫
soluble interleukin-2
receptor(sIL-2R)
LE nephritis(LN)
cellular immunity
