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奥美拉唑肠溶片致白细胞减少 被引量:11

Omeprazole enteric coated tablets-reduced leucopenia
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摘要 39岁女性反流性食管炎、慢性胃窦炎患者,给予奥美拉唑肠溶片20mg,2次/d,以及多潘立酮片和铝碳酸镁咀嚼片。服药2周后,患者出现困倦、乏力、纳差、低热。WBC由6.3×109/L降到3.6×109/L。将奥美拉唑改为雷尼替丁150mg,2次/d,多潘立酮片、铝碳酸镁咀嚼片继续服用,加服利血生20mg,3次/d。3d后,WBC升至4.2×109/L。随访患者血细胞恢复正常。 A 39-year-old female patients with reflux esophagitis and antral chronic gastritis was administered with omeprazole enteric coated tablets 20 mg twice daily, domperidone tablets, and hydrotalcite chewable tablets. After two weeks treatment, she developed drowsiness, fatigue, anorexia, and low fever. Her count of WBC decreased from 6.3 ×10^9/L to 3.6×10^9/L. Omeprazole was replaced with ranitidine 150 mg twice daily. Domperidone and hydrotalcite therapy was continued, and leucogen 20 mg thrice daily was added to her regimen. Three days later, her count of WBC increased to 4.2 ×10^9/L. At follow-up, her blood cell count restored to normal limits.
出处 《药物不良反应杂志》 2007年第5期366-367,共2页 Adverse Drug Reactions Journal
关键词 奥美拉唑 白细胞减少 omeprazole leukopenia
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