摘要
为深入了解移植免疫生物学反应，对广东地区２５７２例肾移植患者术前进行群体反应性抗体（ＰＲＡ）检测及移植后发生严重排斥反应等指标的观察，以研究ＰＲＡ对肾脏移植的影响。研究证实：ＰＲＡ介导超急性排斥反应，承担移植物早期丧失的责任。移植、妊娠和输血等致敏过程可刺激机体产生ＰＲＡ，ＰＲＡ＞５０％与发生超急等严重排斥反应密切关联，对肾移植构成威胁，认为ＰＲＡ分析应列入组织配型程序。
Panel reactive antibody (PRA)was detected before kidney transplantation in 2 572 cases in Guangdong province of China.The result showed hyperactive reaction after kidney transplantation was mediated through PRA leading to the loss of allograft in the early stage.A past history of transplantation,pregnancy or blood transfusion might cause the production of PRA.PRA level higher than 50% would be correlated with hyperactive rejection resulting in the loss of the allograft.So,PRA detection before kidney transplantation is recommended in tissue typing protocol for kidney transplantation.
出处
《中华泌尿外科杂志》
CAS
CSCD
北大核心
1997年第6期337-340,共4页
Chinese Journal of Urology
