摘要
目的探讨左卡尼汀对血液透析患者群体反应性抗体的影响。方法50例群体反应性抗体增高的血液透析患者随机分为两组,左卡尼汀治疗组30例,对照组20例,治疗组患者在每次透析结束后静脉注射左卡尼汀2.0g,疗程6个月,对照组不给药。采用ELISA方法对50例患者治疗前后群体反应性抗体进行检测。结果左卡尼汀治疗组群体反应性抗体显著下降,而对照组群体反应性抗体无显著变化,治疗后两组之间比较差异显著(P<0.01)。结论左卡尼汀可降低血液透析患者群体反应性抗体。
Objective To explore the effecl of L-carnitine on panel reaclive anlibody （PRA） in hemodialysis patienls. Methods 50 patients were classified randomly into 2 groups： L-carnitine group receiving intravenous injection of 2g L-carnitine after each hemodialysis for 6 months, and control group did not receive any L-carnitine treatment. The PRA in serum was measured by enzyme-linked immunosorbent assay （ELISA） before and after 6 monlhs of L-carnitine treatment. Results L-carnitine significantly reduced PRA levels compared with control group（P〈0. 01）. PRA levels in L-carnitine group decreased significantly, with an average decrease of 22. 45G. Conclusion L- carnitine could reduce PRA levels significantly in highly sensitized patients.
出处
《解放军医学杂志》
CAS
CSCD
北大核心
2005年第12期1110-1111,共2页
Medical Journal of Chinese People's Liberation Army
关键词
肾移植
肾透析
群体反应性抗体
左卡尼汀
kidney transplantation
renal dialysis
panel reactive antibody
L-carnitine
