摘要
采用手性铜催化剂(S)-7644,利用重氮醋酸不饱和酯的分子内不对称卡宾加成环化,合成了七个光学活性3-氧杂双环[3.1.0]-己-2-酮类化合物。产品经元素分析、红外、核磁确证了结构,并测定了比旋光度和光学收率。
Seven optically active 3 - oxabicyclo -[3.1.0]- hex - 2 - one derivatives (or bicyclic lactones) were prepared from unsaturated esters of diazoacetic acid by the asymmetric intramolecular carbene addition under the action of a chiral copper catalyst, (S) - 7644. The merit of this method is its simple operation using commercially available reagents. The structure of the products obtained were confirmed by elemental analysis, IR, NMR and the specific rotation, the e. e. values were also determined.
出处
《有机化学》
SCIE
CAS
CSCD
北大核心
1997年第1期76-81,共6页
Chinese Journal of Organic Chemistry
基金
安徽省自然科学基金
安徽省教委基金
关键词
不对称合成
分子内环化
氧杂双环己酮
asymmetric synthesis, 3 - oxabicyclo - [3. 1.0] - hex - 2 - one, bicyclic lactone, intramolecular, unsaturated ester, e. e.
