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单肺通气与一氧化氮

One-lung ventilation and nitric oxide
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摘要 一氧化氮(nitric oxide,NO)是一种内皮源性舒张因子,具有松弛血管平滑肌、抑制血小板聚集和参与神经介质传递的主要信号转导等多种生物效应。内皮衍生的NO对维持正常的体循环和肺循环的血管紧张性起着重要作用。吸入NO可选择性地降低肺血管阻力、改善肺的氧合功能。内源性NO在单肺通气中对肺血流有重要的调节作用,理论上吸入NO能选择性舒张肺血管,对单肺通气中低氧血症具有治疗作用。现就近年来关于NO以及吸入NO在单肺通气中对肺血流调控等进展作一综述。 Hypoxaemia often occurs during one - lung ventilation （OLV）. Endogenous nitric oxide （NO） is an important vascular regulator to dilate pulmonary vascular bed and increase blood flow to ventilated lung. This article will review the mediation of NO on pulmonary blood flow during OLV and the therapeutical effect of endgenous NO on OLV - induced hypoxaemia.
作者 魏昕 方才
机构地区 安徽省立医院麻醉科
出处 《国际麻醉学与复苏杂志》 CAS 2007年第5期457-459,共3页 International Journal of Anesthesiology and Resuscitation
关键词 单肺通气 一氧化氮 内皮源性舒张因子 肺血流调控 one - lung ventilation nitric oxide
分类号 R614 [医药卫生—麻醉学]
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参考文献15

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二级参考文献12

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国际麻醉学与复苏杂志
2007年 第5期

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