摘要
目的:研究迎春花水提取物对脑缺血缺氧损伤保护作用。方法:采用结扎小鼠双侧颈总动脉和迷走神经的方法;采用化学法观察迎春花对缺血再灌注小鼠脑组织中超氧化物歧化酶(SOD)、丙二醛(MDA)和谷胱甘肽(GSH)的含量。结果:迎春花腹腔注射可明显延长小鼠耐缺氧时间,增强脑组织中SOD的活性,降低MDA的含量,增加GSH含量。结论:迎春花对脑缺血再灌注损伤具有显著的保护作用,其机制可能抗氧化作用有关。
Object： To study the protective effect of Jasminum nudiflorum Lindl water extract against cerebral ischemia-reperfusion iniury. Methed ： The survival time of mice was recorded after ligating bilateral common carotid arteries and vagus nerves in mice. The activity of superoxide dismutase （SOD） ,the contents malondialdehyde（MDA） and glutathione （GSH） were determined by spectrophotometry in brain homogenate of mice. Results ：JNLWE significantly prolonged the survival time of mice, enhanced the activity of SOD, degraded the contents of MDA and raised the contents of GSH in the brain induced by ischemia-reperfusion. Conclusion ：JNLWE has protective effect against cerebral ischemia-reperfusion injury via its antioxidant activity.
出处
《中药药理与临床》
CAS
CSCD
北大核心
2007年第5期133-135,共3页
Pharmacology and Clinics of Chinese Materia Medica
关键词
迎春花
缺血再灌注
抗氧化
Jasminum nudiflorum Lindl
iachemia-reperfusion
antioxidant activity
