摘要
以2,4,6-三羟基苯乙酮和2,4-二羟基苯甲醛为起始原料,经过异戊烯基取代、选择性保护羟基、Mitsunobu反应、Claisen重排、醛酮缩合、催化环化及去保护基等步骤,首次完成了天然异戊烯基黄烷酮CudraflavanoneB的全合成,同时也完成了(±)-5-O-甲基-6-(2"-异戊烯基)-7,2',4'-三羟基黄烷酮的全合成研究.
The total synthesis of natural Cudraflavanone B was first achieved through selective protection of phenolic hydroxyl groups, Mitsunobu reaction, Claisen rearrangement, condensation, cyclization and deprotection starting from 2,4,6-trihydroxyacetophenone and 2,4-dihydroxybenzaldehyde. Meanwhile, the total synthesis of （±）-5-O-methyl 6-（2″ -prenyl）-7,2′,4′-trihvdroxvflavanone was also finished.
出处
《化学学报》
SCIE
CAS
CSCD
北大核心
2005年第20期1901-1905,共5页
Acta Chimica Sinica
基金
国家自然科学基金(No.20472025
TQNo.20021001)资助项目.
