摘要
目的探讨慢性肾功能衰竭患者血浆血管性血友病因子(von Willebrand factor,vWF)的含量变化及临床意义。方法收集慢性肾功能衰竭患者血清36份(观察组),其中原发性肾病26例,继发性肾病10例,正常体检者20例作为对照组,进行vWF水平测定,并比较其结果。结果观察组总体vWF水平较正常对照组显著升高,其数值为(394.36±133.35)%vs(108.3±15.87)%(P<0.01),根据病因分组后比较发现,原发性肾病患者与继发性肾病患者vWF无明显差异(P>0.05);病情变化过程中vWF含量与血肌酐呈明显正相关(r=0.834,P<0.01)。结论肾功能衰竭患者广泛存在血管内皮细胞受损,动态监测vWF的含量对帮助判断肾功能衰竭患者血管内皮状态,和是否选择相应的保护治疗手段有重要的提示价值。
Objective To investigate the change of plasma von Willebrand factor （vWF） level and clinical significance in the patients with chronic renal failure（CRF）. Methods Thirty-six cases of patients with chronic renal failure （26 cases of primary CRF and 10 cases of secondary CRF） ,and 20 cases in control group were measured of their vWF and the results were compared. Results The level of vWF in the patient group was all significantly higher than that of control group, （394. 36± 133.35） % vs （108.3±15.87）%（ P 〈0. 01） ,but there was no significant difference in plasma vWF between primary CRF and secondary CRF group（ P 〉0.05）. There was a positive correlation between the levels of plasma vWF and serum creatinine in the patients with impaired renal function （ r = 0. 834, P〈 0.01）. Conclusion There were extensive vascular endothelial ceils impaired in the patients with CRF. It is important to continuously detect vWF levels, for the evaluation of the endothelial ruction of CRF patients and the choice of appropriate therapeutic regimen.
出处
《临床荟萃》
CAS
北大核心
2007年第20期1465-1467,共3页
Clinical Focus
关键词
肾功能衰竭
慢性
因子Ⅷ
肌苷
kidney failure, chronic
factor Ⅷ
inosine
