摘要
目的探讨不同胃疾病患者血清ｈＥＧＦ含量变化的临床意义．方法用ＲＩＡ法测定慢性胃炎（ＣＧ）患者５５例，胃癌（ＧＣ）患者１３例及胃溃疡（ＧＵ）患者１１例血清人表皮生长因子（ｈＥＧＦ）含量，并与２１例正常健康人对照分析．结果与正常人血清ｈＥＧＦ含量（０７８μｇ／Ｌ±０２７μｇ／Ｌ）比较，ＣＧ患者血清ｈＥＧＦ含量显著升高（１５８μｇ／Ｌ±０２０μｇ／Ｌ，Ｐ＜００５），ＧＵ患者ｈＥＧＦ含量明显降低（０４５μｇ／Ｌ±０１３μｇ／Ｌ，Ｐ＜００５），而ＧＣ患者ｈＥＧＦ含量则无明显变化（１１７μｇ／Ｌ±０３３μｇ／Ｌ，Ｐ＞００５）．按慢性胃炎病变程度比较见慢性浅表性胃炎（ＣＳＧ）、轻度及中、重度慢性萎缩性胃炎（ＣＡＧ）患者血清ｈＥＧＦ均高于正常人（１４９μｇ／Ｌ±０３７μｇ／Ｌ，１５２μｇ／Ｌ±０３５μｇ／Ｌ及１６６μｇ／Ｌ±０２８μｇ／Ｌ与０７８μｇ／Ｌ±０２７μｇ／Ｌ，Ｐ＜００５），且随着病变程度的加重，ｈＥＧＦ含量有升高的趋势．结论慢性胃炎、胃溃疡患者ｈＥＧＦ含量异常与其发病及病理过程密切相关．
AIM To study the level changes and clinical significance of human epidermal growth factor in serum of the patients with chronic gastritis (CG), gastric carcinoma (GC) and gastric ulcer (GU). METHODS By using radioimmunoassay (RIA), the levels of hEGF were measured in 79 cases of gastric diseases, including 55 of chronic gastritis (CG), 13 of gastric carcinoma (GC) and 11 of gastric ulcer (GU), and in 21 normal controls (NC). RESULTS Comparing with normal controls (NC), hEGF in CG group was increased significantly (1 58μg/L±0 20μg/L vs 0 78μg/L±0 27μg/L P <0 05) and decreased in GU group (0 45μg/L±0 13μg/L vs 0 78μg/L±0 27μg/L, P <0.05). But there was no difference between GC and NC (1 17μg/L±0 33μg/L vs 0 78μg/L±0 27μg/L, P >0 05). According to the classification of CG, hEGF in all kinds of CG (chronical superficial gastritis, mild, moderate and severe chronic atrophic gastritis) were increased more than normal controls (1 49μg/L±0 37μg/L, 1 52μg/L±0 35μg/L, 1 66μg/L±0 23μg/L vs 0 78μg/L±0 27μg/L, P <0 05). CONCLUSION The hEGF levels were associated significantly with the pathogenesis and pathologic changes in chronic gastritis and gastric ulcer.
