摘要
目的探讨低分子肝素口服制剂对肝损伤家兔血液流变学及肝脏微循环的影响．方法家兔３０只随机分为Ａ组（正常对照）、Ｂ组（仅腹腔注射Ｄ－氨基半乳糖）、Ｃ组（低分子肝素治疗组），测定其血液流变学并观察肝脏微循环改变．结果用药后２４ｈ和７２ｈ观察，同Ａ组相比，Ｂ组平均血流量（１７４±５２，１４２±１４ｖｓ３２５±１０１，Ｐ＜００１）和极差（２３±１４，１３±０６ｖｓ４３±２７，Ｐ＜００５）明显降低，低切粘度（１０１１ｍＰａ·Ｓ－１±０５６ｍＰａ·Ｓ－１，８０４ｍＰａ·Ｓ－１±０７５ｍＰａ·Ｓ－１ｖｓ７２８ｍＰａ·Ｓ－１±０６１ｍＰａ·Ｓ－１，Ｐ＜００５）、高切粘度（５０４ｍＰａ·Ｓ－１±０３６ｍＰａ·Ｓ－１ｖｓ４７５ｍＰａ·Ｓ－１±０２７ｍＰａ·Ｓ－１，Ｐ＜００５）、血浆粘度（１７５ｍＰａ·Ｓ－１±０１３ｍＰａ·Ｓ－１ｖｓ１６９ｍＰａ·Ｓ－１±００９ｍＰａ·Ｓ－１Ｐ＜００５）、红细胞聚集指数（２０７±０１３，１９１±０３７ｖｓ１３６±００８，Ｐ＜００１）明显升高，血沉和红细胞压积无显著改变．Ｃ组同Ｂ组相比，高切粘度（４３８ｍＰａ·Ｓ－１±０?
AIM To study the effects of low molecular weight heparin (LMWH) oral preparation on hemorrheology of rabbit liver damaged by D-galuctosamine (D_GalN). METHODS Thirty rabbits were randomly divided into 3 groups : A (normal control), B(400mg/kg D_GalN were injected into abdominal cavity), C(treatment group, 1000U/kg LMWH were perfused twice a day for 3 days after D_GalN was injected). The hemorrheologic indexes were measured and hepatic microcirculation were observed. RESULTS Compared with group A, Group B had lower average blood flow, higher low and high shear blood viscosity and plasma viscosity, the index of RBC aggregation became highter ( P <0 05), the hemotocrit and ESR were not obviously changed. Group C as compared with group B, showed that the average blood flow, high and low shear viscosity, index of RBC aggregation became lower, hepatic microcirculation improved significantly ( P <0 05), and the hemotocrit and ESR were not obviously changed. CONCLUSION LMWH oral preparation can improve the hemorrheology and hepatic microcirculation of rabbit liver damaged by D_GalN.
