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凋亡调节蛋白Survivin与类风湿关节炎 被引量：2

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摘要 凋亡调节蛋白（Survivin）是最近新发现的凋亡抑制蛋白（inhibitor of apoptosis proteins，IAP）家族的新成员，具有抑制细胞凋亡和调节细胞有丝分裂的双重功能，是联系细胞周期和细胞凋亡的重要因子。类风湿关节炎（rheumatoid arthritis，RA）是一种以关节滑膜浸润性增生为主要病理改变的自身免疫疾病。研究表明，滑膜细胞周期失调及凋亡异常可导致关节滑膜组织过度增生、肥厚，从而促进RA发生。这些异常的凋亡与凋亡相关基因Fas、Bcl-2、p53、survivin等表达异常有关。本文就Survivin与RA之间的关系综述如下。
作者 高娜 张育
机构地区 扬州大学临床医学院血液风湿科
出处 《中华风湿病学杂志》 CAS CSCD 2007年第11期690-693,共4页 Chinese Journal of Rheumatology
关键词 SURVIVIN 凋亡调节蛋白 类风湿关节炎 APOPTOSIS SURVIVIN 关节滑膜组织 滑膜细胞周期 凋亡抑制蛋白
分类号 R593.22 [医药卫生—内科学]
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参考文献22

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二级参考文献126

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中华风湿病学杂志
2007年 第11期

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