摘要
目的探讨帕罗西汀联合心理干预对伴发抑郁症的功能性消化不良患者的临床疗效。方法将108例伴有抑郁症焦虑症状的功能性消化不良病人随机分为:抗消化不良组,抗抑郁并心理干预组,综合治疗组。分别给予单抗消化不良治疗,单抗抑郁并心理干预治疗,合并2种方法治疗。疗程均为8周。结果3组患者的上腹胀、早饱、上腹痛、上腹烧灼感症状评分、Zung自评量表评分和HAMD量表评分,均较治疗前下降。综合治疗组消化不良症状控制总有效率为86.1%,HAMD量表评分达常模有效率为86.1%,高于抗消化不良组的36.1%和11.1%,抗抑郁组的44.4%和16.7%,差异均有显著性。结论对伴有抑郁焦虑症状的功能性消化不良患者,在治疗时联合使用抗抑郁药及心理干预,能明显提高临床疗效。
Objective To explore the clinical curative effect of paroxetine combined with psychological intervention on depressive disorder in functional dyspepsia（FD）. Methods 108 cases of FD with anxious depressive manifestations were randomizely allocated into antidyspepsia group, paroxetine with psychological intervention group and antidepressants combination group. All patients were treated for 8 weeks. Results FD scores（ upper abdominal distention, satiety, abdominal pain, epigastric burning sensation） with Zung depression scale and HAMD scale descreased after treatment in all three groups. Symptoms in combination group improved with a total efficacy rate of 86. 1% ,and HAMD efficacy rate 86. 1%. Both were much higher than those in antidyspepsia group （ 36. 1% and 11.1%, respectively, P 〈 0. 05 ）, and paroxetine with psychological intervention group（44. 4% and 16.7% ,respectively, P 〈 0. 05 ）. Conclusion Antidepressants combined with antidyspeptic medicine is helpful in the treatment of FD patients with anxious depressive manifestations.
出处
《临床消化病杂志》
2007年第5期294-295,298,共3页
Chinese Journal of Clinical Gastroenterology
