溃疡性结肠炎肠黏膜损伤与白细胞介素-13调控
摘要
参与溃疡性结肠炎（UC）肠黏膜炎性反应的细胞和细胞因子不同于克罗恩病（CD）。在UC，聚集于肠黏膜固有层的CD4T淋巴细胞分泌大量白细胞介素（IL）-5等细胞因子，而IL-4、IL-12和γ干扰素（IFNγ）等却无显著变化；值得注意的是，CD1d标志的自然杀伤T细胞（NKT）分泌IL-13显著增高。UC的这种以IL-5和IL-13增高为特征的肠黏膜病变被称之为非典型Th2型免疫性炎症损伤。
出处
《中华消化杂志》
CAS
CSCD
北大核心
2007年第10期715-717,共3页
Chinese Journal of Digestion
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