摘要
目的探讨海洋药物藻酸双酯钠(PSS)的免疫调节作用及其构效关系。方法采用体外免疫细胞培养法检测PSS及其分级产物的免疫调节作用,根据分级产物结构差异,探讨PSS分级产物的免疫活性构效关系。结果PSS能够促进脾脏淋巴细胞的增殖,提高巨噬细胞吞噬功能,同时能抑制刀豆蛋白A(ConA)及脂多糖(LPS)促进的免疫细胞的增殖作用。结论PSS具有显著的免疫调节作用,不同的糖链长度对免疫细胞作用不同。
Objective To investigate the influence of sulfated propylene glycol alginate （PSS） and its fractions on the immunoregulation. Methods The immunoregulation activity of PSS and its fractions were investigated by using immunocyte cultivation technique in vitro. The structure activity relationship was analysed on the basis of the structure studies of PSS fractions. Results The experimental results showed that PSS could improve spleen cell proliferation, enhance macrophage phagocytic function and inhibit T-cell and B-cell proliferation. Conclusion PSS possessed significant immunoregulation effect, whilst the immunocompetence comparison of PSS fractions proved that the different immunocytes had different requirements for saccharides length.
出处
《中国海洋药物》
CAS
CSCD
2007年第5期13-16,共4页
Chinese Journal of Marine Drugs
基金
国家自然科学基金(30130200)
关键词
藻酸双酯钠
多糖
相对分子质量
免疫调节
sulfated propylene glycol alginate
polysaccharides
molecular weight
immunoregulation
