摘要
本文采用两个大气压氧与低pH值（5．5及6．9）相结合培养大鼠甲状腺组织48小时，将甲状腺组织块移植入受体的肾包膜下，从T3、T4均值、平均体重增长及移植组织观察四个方面评价移植物存活及排斥反应情况。结果发现，此方法可减弱排斥反应，延长移植物存活时间，培养后滤泡间过客白细胞并未完全去除，提示此方法以改变主要组织相容性抗原为主。
The thyroid allografts in rats were cultured for 48 h in the cQnditions of hyperbaric oxygen (a mixture of 95 % O2, 5 % CO2 pressurized at 2 atmospheres) and low pH (5. 5 and 6. 9).Uncultured and air cultured allografts were taken as control groups. The thyroid slices were transplanted under the kidney capsulse of thyroidectomized recipients. By examining histological changes, detecting the serum T3 and T4 levels and five weeks body weight gain, the graft survival was cvaluated. Though the thyroids cultured in hyperbaric O2, were contaminated with the passenger leukocytes, the grafts had prolonged survival, suggesting this method might effectively diminish MHC immunogenicity to thyroid grafts.
出处
《中华器官移植杂志》
CAS
CSCD
1997年第2期93-95,共3页
Chinese Journal of Organ Transplantation
