摘要
目的 探讨如何使用药物来保持、提高角膜微型刀上皮下准分子激光角膜磨镶术（Epi-LASIK）术后早期上皮瓣活性。方法 2006年4月至9月在我院行Epi-LASIK手术矫正近视患者55例100眼分为四组。Ⅰ组用0.1%艾氟龙眼液4次/d;Ⅱ组双氯芬酸钠眼液4次/d;Ⅲ组术后0.5h内3次0.1%艾氟龙眼液,术后第一天滴0.1%艾氟龙眼液2次,贝复舒眼液4次,术后第二天开始仅用贝复舒眼液4次/d;Ⅳ组术后使用典必殊眼液4次/d;所有药物均在上皮瓣完全修复后即停用。通过随诊术后刺激症状、角膜上皮瓣水肿情况、角膜上皮修复时间、视力四个项目来讨论各组用药效果。结果 激素减轻术后的刺激症状的作用强于非甾体类;使用贝复舒眼液组比使用双氯芬酸钠眼液组上皮水肿消退快,且使用双氯芬酸钠眼液组又比一直使用激素组上皮水肿消退快;一直使用激素的患者上皮瓣修复需要更长的时间;各组视力均经历一个波谷后回升过程,使用贝复舒眼液组有效视力回升较快。结论 早期使用激素眼液（术后即刻至术后第一天）并结合贝复舒眼液有助于减轻Epi-LASIK术后的刺激症状、缩短上皮瓣的修复时间、加快有效视力的恢复。
Objective To study how to use medication to maintain and elevate the early epithelial flap cell viability after Epi-LASIK（ epipolis laser in-situ keratomileusis ）.Methods Fifty-five patients （100 eyes） treated with Epi-LASIK between April and September 2006 were analyzed, and were randomly allocated four groups.Patients in group Ⅰ used 0.1% Fluorometholone （FML） eye drops q.i.d; Patients in group Ⅱ used Diclofenac Sodium eye drops q.i.d;Patients in group Ⅲ used three times drops 0.1% Fluorometholone （FML） in the first 30 minutes of postopration and two times drops in the first day of postopration, and started using Recombinant Bovine Basic Fibroblast Growth Factor （rb-bFGF） eye drops q.i.d after the flrst postoperative day ;Patients in group Ⅳ used Tobradex （Tobramyc in＋Dexamethasone） eye drops q.i.d.All medication were stopped after epithelial recovery.To compare the effects of four groups by evaluating irritation symptom . area of epithelial edema, the mean time of epithelial recovery, visual acuity（VA）.Results Patients used corticosteroids eye drops had less discomfort than patients used NSAID eye drops;Area of epithelial flap edema reduced more quickly in Patients used rb-bFGF eye drops than used Diclofenac Sodium eye drops, and the recovery of Patients used corficosteroids eye drops was most slowly; All patients recovered vision has a avalley, then to rise gradually; Patient＇s vision used rb-bFGF eye drops recovered more quickly.Conclusions Corticosteroids eye drops were used in the early stage （the first 30 minutes and the first day of postopration）and rb-bFGF eye drops were used （after the first postoperative day） are beneficial for alleviating discormfort, shorting the mean time of epithelial recovery and accelerating vision recovered.
出处
《中国实用眼科杂志》
CSCD
北大核心
2007年第9期953-957,共5页
Chinese Journal of Practical Ophthalmology
