摘要
本文报告了４８例苯接触和慢性苯中毒患者周围血和骨髓常规检查结果。结果显示，周围血白细胞、血小板计数和骨髓有核细胞、巨核细胞计数按苯接触和中毒轻、中、重程度依次递减，血红蛋白含量在重度中毒时才明显减少。在中、重度苯中毒组的骨髓细胞分类中可见粒系和红系原幼和早幼细胞比例减少，提示苯对骨髓造血细胞增殖有抑制作用。骨髓细胞形态改变在各组中均可见到；粒系细胞的形态改变以中毒颗粒和空泡为多见，还可见核分叶过少或过多、核分裂、核固缩、核肿胀或核畸形；红系细胞以核分裂为多见，其他有浆中出现豪乔氏小体和点彩、脱核障碍、巨幼样变；个别患者出现异形淋巴细胞和巨大血小板等；可见苯亦影响血细胞的分化和成熟。以上结果提示，周围血常规检查可在一定程度上反映骨髓的造血功能状况。因此，苯接触工人的定期健康检查和苯中毒患者的随访中，将周围血常规作为过筛检查是可取的。
The results of routine peripheral blood and bone marrow examinations among 48 cases of chronic benzene intoxication and benzene overexposure were reported.The results showed that peripheral white blood cell count,platelet count,karyocyte and megalokaryocyte count of bone marrow were parallelly decreased with the severity of poisoning.Oligochromemia was only found in severe poisoning cases.In bone marrow cell classification,there was some decrease of pronormoblast,myeloblast,prorubricyte and promyelocyte in moderate and severe poisoning,which indicated the suppression of hemopoietic function.The morphological change of bone marrow cell could be found in all cases,such as toxic granule and cytoplasmic vacuoluseven abnormal lobe number,karyokinesis,karyopyknosis,nucleusswelling and nucleus deformity in granulocyte series,karyokinesis or Howell Jolly bodies,stippling red cell,denucleation disturbance,megaloblast in erythrocyte series,heterolymphocyte and enormous platelet etc,which indicated that benzene had the toxic effects on differentiation and maturation of blood cells as well.It should be concluded that the routine peripheral blood examination might in some degree reflect the hemopoietic function of bone marrow and might be a simple way for medical screening or survillance of benzene exposed workers and the follow up of the benzene poisoning patients.
出处
《中国工业医学杂志》
CAS
1997年第1期7-11,共5页
Chinese Journal of Industrial Medicine
关键词
苯作业工人
外周血检查
骨髓检查
苯中毒
Benzene workers Peripheral blood examination Bone marrow examination Clinical application
