摘要
目的:观察阿立哌唑治疗儿童孤独症和精神发育迟滞的多动及冲动等行为障碍的疗效及不良反应。方法:对48例儿童孤独症和精神发育迟滞,给予阿立哌唑治疗。疗程4周。在治疗前及治疗2、4周对其进行Conners父母量表评定,并观察不良反应。结果:治疗2周,品行问题、学习问题、心身障碍、冲动-多动、焦虑、多动等症状即有显著改善(P<0.001)。治疗4周改善更明显。不良反应少。结论:阿立哌唑能有效治疗精神发育迟滞和儿童孤独症的冲动及多动行为,不良反应少。
Objective： To observe the efficacy and side effects of aripiprazole in the treatment of autism or mental retardation in child and adolescent. Method： Forty-eight children and adolescents diagnosed with autism or mental retardation accompanying with behavior disorder were treated by aripiprazole. Conners parents scale were assessed before treatment and at the end of 2nd and 4th weeks. The side effects were also observed. Results： Compared with the baseline, conduct problem, learning problem, psychosomatic disorder, impulsiveness, anxiety and hyperactive were improved significantly at the end of 2nd week （ P 〈 0. 001 ）. At the end of 4th week, these symptoms were improved further. There were few side effects. Conclusion：Aripiprazole may improve the symptoms of impulsiveness and hyperactive behavior disorder in autism or mental retardation in child and adolescent and has few side effects.
出处
《临床精神医学杂志》
2007年第5期333-334,共2页
Journal of Clinical Psychiatry
