摘要
目的:筛选和确定新疆阿魏抗溃疡的有效组分。方法:以雷尼替丁作阳性对照,选择大鼠幽门结扎所致、小鼠利血平诱发、冰醋酸烧灼型3种胃溃疡模型,研究新疆阿魏挥发油、多糖、树胶3组分的抗溃疡作用。结果:挥发油均可使所致大鼠胃液pH值升高、胃蛋白酶活性降低以及溃疡指数降低,树胶也可使大鼠胃液pH值升高、胃蛋白酶活性降低和溃疡指数降低;挥发油组均对利血平所致小鼠胃溃疡有预防作用并明显降低溃疡指数;挥发油0.05mL.kg-1组对冰醋酸烧灼的大鼠胃溃疡面积均显著小于NS对照组(P<0.01),优于雷尼替丁阳性组(P<0.05)。树胶150mg·kg-1剂量组和75mg·kg-1剂量组均显著小于NS对照组(P<0.05)。结论:阿魏中挥发油为其有效组分,疗效有优于雷尼替丁的趋势,树胶为协同成分。
Objective： To preparatory and determinate the efficacious antiulcerative composition of the Ferula sinkiangensis K. M. Shen. Methods： Investigating the antiulcerative action of volatile oils, polysaccharides, gums included in Ferula sinkiangensis K. M. Shen, ranitidine will be employed in positive contrast group; Results： The volatile oils can cause the pH value in the stomach of rats increase, conversely pepsin activity will decrease, then ulcerative index reduce as the uhimate resuh, the same effect to gums. The volatile oils can significantly prevent gastric ulcer resuh from reserpine in mice of volatile oils group and suppress ulcerative index. Therapy with 0.05mL.kg^-1 volatile oils, gastric ulcer of mice caused by acetic acid whose area apparently less than that in NS control group （P 〈 0.01 ）, better than results came from ranitidine positive group （P 〈 0.05 ） . In both 150mg. kg^-1 and 75mg. kg^-1 gums groups, the datum indicates that therapeutic effects are prominently better than those from NS control group （P 〈 0.05 ） . Conclusion： The volatile oils are the efficacious composition in Ferula sinkiangensis K. M. Shen, there is the tendency that the therapeutic actions offered by Ferula sinkiangensis K. M. Shen are superior to those of ranitidine, and the gums are coordinated composition.
出处
《中国现代中药》
CAS
2007年第10期8-10,共3页
Modern Chinese Medicine
基金
新疆维吾尔自治区自然科学基金资助项目(20008)
关键词
新疆阿魏
抗溃疡
Ferula sinkiangensis K. M. Shen
Antiulcerative action
