摘要
目的探讨儿童多米诺肝移植的可行性和安全性。方法将一成人左外叶移植给家族性高胆固醇血症3岁男性患儿,同时采用多米诺肝移植技术将该患儿的肝脏移植给先天性胆道闭锁4个月女性患儿。结果家族性高胆固醇血症患儿的血清总胆固醇及低密度脂蛋白于术后第三天降至正常范围,手术后第8天死于心力衰竭。先天性胆道闭锁患儿随访16个月,肝肾功能化验正常,血清总胆固醇及低密度脂蛋白分别为8.87 mmol/L和6.21 mmol/L,明显低于多米诺供体患儿的术前水平。结论尽管术后多米诺受者出现获得性高胆固醇血症,但FHC可以作为多米诺供肝,近期效果满意,远期效果需进一步观察。
Objective To discuss the feasibility and reliability of Domino liver transplantation in children. Methods One 4-year old child with familial hypercholesterolemia （FHC） received left-lateral segment of a adult split liver, his liver was then transplanted into a 4-months old infant with biliary atresia. Results The serum cholesterol of the child with familial hypercholesterolemia was normal at 3 days after transplantation, but he died of cardiac failure at 8 days after transplantation. After 16 months follow-up, the serum cholesterol and LDL in child with biliary atresia were 8. 87 mmol/L and 6. 21 mmol/L, and the functions of liver and kidney showed normal in this child. Conclusions The child with FHC can become the donor for the Domino liver transplantation, further study is still necessary on long term outcomes.
出处
《中华小儿外科杂志》
CSCD
北大核心
2007年第10期522-524,共3页
Chinese Journal of Pediatric Surgery
关键词
肝移植
高胆固醇血症
家族性
儿童
Liver transplantation
Hypercholesterolemia familial
Child
